Thorn Lab

Papers 2010-present

• Liang T, Dolai S, Xie L, Winter E, Orabi AI, Karimian N, Cosen-Binker LI, Huang YC, Thorn P, Cattral MS, Gaisano HY (2017) Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology. J Biol Chem 292: 5957-5969

• Gan WJ,  Zavortink M, Ludick C, Templin R, Webb R, Webb R, Poronnik P, Parton RG, Gaisano HY, Shewan AM, and Thorn P (2017) Cell polarity defines three distinct domains in pancreatic beta cells. Journal of Cell Science, 130: 143 -51

• Han Y, Shewan AM and Thorn P (2016) HCO3- transport through anoctamin/transmembrane protein ANO1/TMEM16A, in pancreatic acinar cells, regulates luminal pH. J Biol Chem 291:  20345-20352

• Do OH, Gunton J, Gaisano HY and Thorn P (2016) Changes in beta cell function occur in prediabetes and early disease in the Leprdb mouse model of diabetes. Diabetologia, 59: 1222-1230

• Yu M, Niu Y, Zhang Y, Zhang H, Yang Y, Taran E, Jambhrunkar S, Gu W, Thorn P, and Yu C(2016). Size-dependent gene delivery of amine modified silica nanoparticles. Nano Research, 9, 291-305

• Thorn P and Gaisano HY (2015) Cell-to-cell communication and the regulation of pancreatic function.  Pancreas 44, 1174-1175

• Do OH, Low JT and Thorn P (2015) Insulin secretion from beta cells within intact islets; location matters. Clinical & Experimental Pharmacology & Physiology, 42, 406-414

• Do OH, Low JT and Thorn P (2015) Leprdb mouse model of type 2 diabetes: pancreatic islet isolation and live-cell 2-photon imaging of intact islets. Journal of Visualized Experiments Issue 99; doi: 10.3791/52632

• Maisonneuve B, Roux D, Thorn P Cooper-White J, (2015) Effects of Synthetic Biomacromolecule Addition on the Flow Behaviour of Concentrated Mesenchymal Cell Suspensions. Biomacromolecules 16, 275-283

• Low JT, Zavortink M, Mitchell JM, Gan WJ, Schwiening CJ, Gaisano HY, and Thorn P (2014) Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature. Diabetologia 57: 1655-1663

• Do OH,  Low JT, Gaisano HY and Thorn P (2014) The secretory deficit in db/db islets is mainly due to a loss of responding beta cells. Diabetologia 57: 1400-1409

• Yu M, Karmakar S, Yang J, Zhang H, Yang Y, Thorn P and Yu C. (2014) Facile synthesis of ultra-small hybrid silica spheres for enhanced penetration of 3D glioma spheroids. Chem Comm  50, 1527-1529.

• Meihua Y, Yuting N, Yannan Y, Sandy BH, Jie Y, Thorn P, Xiaodan H and Yu C. (2014) A novel approach to prepare polyethyleneimine functionalized silica-based spheres with small size for siRNA delivery. ACS Applied Materials and Interfaces. 6: 15626-15631

• Thorn P. (2014) Measurement of dynamic F-actin changes during exocytosis. Methods in Molecular Biology. 1174:423-431

• Jiun T. Low , Justin M. Mitchell, Oanh H. Do, Jacinda Bax, Alicia Rawlings, Michael Zavortink, Garry Morgan, Robert G. Parton, Herbert Y. Gaisano and Peter Thorn (2013).  Glucose principally regulates insulin secretion in islets by controlling the numbers of granule fusion events per cell. Diabetologia 56: 2629-2637

• Maisonneuve B, Roux, D.C.D. Thorn, P. & Cooper-White, J.J.  (2013) Effects of cell density and biomacromolecule addition on the flow behaviour of concentrated mesenchymal cell suspensions. Biomacromolecules 14 12: 4388-4397

• Meihua Yu., Gu W., Jambhrunkar S., Thorn P., Chen J., Yu  C . (2013) Hyaluronic Acid Modified Mesoporous Silica Nanoparticles for Targeted Drug Delivery to CD44-overexpressing Cancer Cells. Nanoscale 5: 178-183.

• Thorn,P. Measuring calcium signals and exocytosis in tissues. (2012) Biochemica et Biophysica Acta – General Subjects 1820(8):1179-84.

• Thorn, P. and Gaisano H.Y. (2012) Molecular control of compound exocytosis: a key role for VAMP8. Communicative and integrative Biology 5, issue 1, 61-63.

• Jang Y., Soekmadji C., Mitchell, J.M, Thomas, W.G. and Thorn, P. (2012)  Real-time measurement of F-actin remodelling during exocytosis using Lifeact-EGFP transgenic animals. PLOS One 7(7): e39815.

• Meihua Yu., Zhou, L., Zhang, J., Yuan, P., Thorn, P., Gu, W., Yu, CY. (2012) A Simple Approach to Prepare Monodisperse Mesoporous Silica Nanospheres with Adjustable Sizes Journal of Colloidal and Interface Science 376(1):67-75.

• Bugarcic, A., Zimbardi, K., Macaranas J. and Thorn P. (2012) An inquiry-based practical for a large, foundation-level undergraduate laboratory that enhances student understanding of basic cellular concepts and scientific experimental design. Biochemistry and Molecular Biology Education 40(3):174-80.

• Mangold S, Wu SK, Norwood SJ, Collins BM, Hamilton NA, Thorn P, Yap AS (2011) Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens. Current Biology 21(6):503-7.

• Jang, Y. & Thorn, P. (2011) Visualization of exocytosis in pancreatic acinar cells by fluorescence microscopy. The Pancreapedia: Exocrine Pancreas Knowledge Base, DOI: 10.3998/panc.2011.15

• Behrendorff, N., Dolai, S., Hong, W., Gaisano, H.Y. & Thorn, P. (2011) Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion. Journal of Biological Chemistry 286, 29627-29634.

• Behrendorff N, Floetenmeyer, M, Schwiening C & Thorn P (2010) Protons, co-released during secretion, are a negative feedback extracellular messenger and contribute to the early tissue damage in secretagogue-induced pancreatitis Gastroenterology 139, 1711-1720.

• Soekmadji, C. & Thorn, P. (2010) Secretory control: evidence for agonist-regulation of post-fusion behaviour. Clinical and Experimental Pharmacology and Physiology 37, 218-221.

• Low J.T., Shukla A., Behrendorff N. & Thorn, P. (2010) Exocytosis, dependent on calcium release from calcium stores, is regulated by calcium microdomains.  Journal of Cell Science 123, 3201-3208

• Low J.T, Shukla A. & Thorn, P. (2010) Pancreatic acinar cell: new insights into the control of secretion. The International Journal of Biochemistry & Cell Biology 42, 1586–1589

What We've Achieved